Ujwala S. Tayade; Jyotsna S. Meshram; Amulrao U. Borse
Abstract
In this study, we have chosen chitosan as capping and stabilizing agent for silica-based hydrogel synthesis. Chitosan, a biomaterial linear polysaccharide gives the pathway to greener synthesis. The source of Silica that has been chosen is sodium silicate which is very cheap when compared to other silanating ...
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In this study, we have chosen chitosan as capping and stabilizing agent for silica-based hydrogel synthesis. Chitosan, a biomaterial linear polysaccharide gives the pathway to greener synthesis. The source of Silica that has been chosen is sodium silicate which is very cheap when compared to other silanating agent. But the more important feature of these hydrogels is that they shows the similar properties in the qualitative and quantitative analysis. The applications of these nanoparticles are also like another silane reagent. The hydrogel was characterized by UV-Visible, FTIR, XRD, and SEM with EDX analysis. The prepared nanoparticle in presence of acidic medium shows the behavior of hydrogel and they swell in water because of hydrophilicity of water. The hydrogel is applicable in drug loading such as isoniazid.
Akshay S. Kulkarni; Geeta Shirnalli; Ashok M. Sajjan; Nagaraj R. Banapurmath; Ashok S. Shettar; Kartik J. Uttarkar
Abstract
A solution technique was adopted to develop membranes in which chitosan-wrapped silver nanoparticles (CS-wrapped Ag nanoparticles) were incorporated in poly(vinyl alcohol) (PVA). The morphological studies and the chemical compositions of the prepared membranes were investigated using the characterization ...
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A solution technique was adopted to develop membranes in which chitosan-wrapped silver nanoparticles (CS-wrapped Ag nanoparticles) were incorporated in poly(vinyl alcohol) (PVA). The morphological studies and the chemical compositions of the prepared membranes were investigated using the characterization techniques like Infrared Spectroscopy, Differential scanning colorimetry, Wide Angle X-ray Diffraction, Thermogravimetric analysis and scanning electron microscopy. The effects of CS-wrapped Ag nanoparticles on membrane swelling were systematically studied to know the gas separation performance of the membranes. TGA showed increased thermal stability of Ag-nanoparticles incorporated PVA membranes nearly twice that of plane PVA membranes. Further, SEM revealed that CS-wrapped Ag nanoparticles incorporation into the PVA membrane matrix showed good compatibility and high swelling properties.
Sudha C. Angadi; Lata S. Manjeshwar; Tejraj M. Aminabhavi
Abstract
Nanocomposite microspheres of chitosan (CS) with magnesium aluminum silicate (MAS) and enteric coated with poly(vinyl acetate phthalate) (PVAP) have been prepared and examined for controlled release (CR) of capecitabine, an anticancer drug. The microspheres have been characterized by X-ray diffraction ...
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Nanocomposite microspheres of chitosan (CS) with magnesium aluminum silicate (MAS) and enteric coated with poly(vinyl acetate phthalate) (PVAP) have been prepared and examined for controlled release (CR) of capecitabine, an anticancer drug. The microspheres have been characterized by X-ray diffraction (XRD) to study the drug distribution, DSC to understand thermal stability and Fourier transform infrared (FTIR) spectroscopy to investigate the chemical interactions as well as to assess the structures of drug-loaded formulations. Surface morphology of the microspheres was investigated by scanning electron microscopy (SEM). The size distribution of the formulated microspheres studied by particle size analyzer was in the range of 303-350 μm, while their encapsulation efficiencies ranged from 50 to 58%. Equilibrium swelling of the microspheres was measured in both pH 1.2 and 7.4 media. In vitro release of capecitabine has shown a dependence on polymer-clay composition, amount of crosslinking agent and extent of enteric coating. The formulations extended the release of drug up to 32 h. The enteric coating with PVAP effectively reduced the burst release of the drug in gastric pH medium. The present method offers promising results for controlled release of short-acting drugs. Copyright © 2018 VBRI Press.
