Document Type : Research Article
Authors
1 School of Chemical Sciences, Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon, Maharashtra, India
2 Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India
Abstract
In this study, we have chosen chitosan as capping and stabilizing agent for silica-based hydrogel synthesis. Chitosan, a biomaterial linear polysaccharide gives the pathway to greener synthesis. The source of Silica that has been chosen is sodium silicate which is very cheap when compared to other silanating agent. But the more important feature of these hydrogels is that they shows the similar properties in the qualitative and quantitative analysis. The applications of these nanoparticles are also like another silane reagent. The hydrogel was characterized by UV-Visible, FTIR, XRD, and SEM with EDX analysis. The prepared nanoparticle in presence of acidic medium shows the behavior of hydrogel and they swell in water because of hydrophilicity of water. The hydrogel is applicable in drug loading such as isoniazid.
Graphical Abstract
Keywords
2001,7, 35.
2.Raphae,R.;He,R.;Anne des,R.;Nicolas,D.;Christine,J.;
Veronique,P.;Adv.Polym.Sci.,2011, 244,19.
3.Banik,N.;Ramteke,A.; Maji, T.; PolymAdvan Technol.,2014,25,
1580.
4.Alves, N.;Mano, J.;Int. J. Biol. Macromol.,2008,43,401.
5. Shirosaki,Y.;Tsuru,K.;Hayakawa,S.;Osaka, A.;Lopes, M.;
Santos,J.;Fernandes,M.;Biomaterials,2005, 26,485.
6.Venter,J.;Kotze,A.;Auzely-Velty,R.;Rinaudo, M.; Int. J.
Pharm,2006, 313,36.
7.Denkbas,E.;Ottenbrite, R.; J.Bioact Compat Pol.,2006, 21,351.
8.Kumirska,J.;Weinhold,M.;Thöming,J.;Stepnowski,P.;Poly.,
2011,3,1875.
9.Sieval,A.;Thanou,M.;Kotze,A.;Verhoef,J.;Brussee,J.;
Junginger,H.; Carbohydr. Polym.,1998,36,157.
10.Qie L., Chen W., Wang Z., Shao Q, Li, X., Yuan L. and Huang Y.;
Adv. Mater., 2012, 24(15): 2047-2050.
11.Pang,H.;Chen,G.;Park,H.;Cha,D.;Kennedy,J.;Carbohydr.
Polym.,2007, 69,419.
12.Vaghani,S.;Patel,M.;Satish,S.;Patel,M.; Jivani, P.; Bull. Mater.
Sci.,2012,35,1133.
13.Di Martino,A.;Sittinger, M.; Risbud, M.;Biomaterials,2005, 26,
5983.
14.Zhu,Y.;Shi J.;Shen W.;Chen,H.;Dong,X.;Ruan,M.;
Nanotechnology,2005, 16,2633.
15.Vermonden,T.;Censi,R.;Hennink,W.; Chem. Rev.,2012,112,
2853.
16.Trewyn,G.;Giri,S.;Slowing,I.;Lin,V.;Chem. Comm.,2007,31,
3236.
17.Wu,S.;Hung,Y.;Mou,C.;Chem. Comm.2011,47,9972.
18.He,Q.;Shi,J.;J.Mater. Chem.,2011,21,5845.
19.Jafarzadeh,M.;Rahman,I.;Sipaut,S.;Cera. Int.,2010,36,333.
20.Skuja,N.;Streletsky,N.;Pakovich, A.; Solid State Commun.,1984,
50,1069.
21.Tohmon,R.;Mizuno,H.;Ohki,Y.;Sasagane,K.;Nagasawa, K.;
Hama,Y.;Phy. Rev. B.,1989,39,1337.
22.Rabea, M.;Mohseni,M.;Mirabedini, S.;Tabatabaei,M.; Appl.
Surf. Sci.,2012,258,4391.
23.Liu,Y.;Su,H.;Lai, J.; Polymer,2004,45,6831.
Mat. Chem. and Phy.,2009,114, 328.
25.Li,X.;Cao,Z.;Zhang,Z.;Dang, H.;Appl. Surf. Sci.,2006, 252,
7856.
26.Banik,N.;Hussain,A.;Ramteke,A.;Sharma, K.;Maji,T.;RSC
Adv.,2012,2, 10519.
27.Mukhopadhyay, P.;Sarkar,K.;Soam,S.;Kundu, P.;J. Appl.
Polym.,2013, 129,835.
28.Won,C.;Nersisyan,H.;Won,I.;Lee,H.; J. Solid State Chem.,
2009,182,3201.
29.Scriba,R.;Britton,D.;Arendse,C.;van Staden, M.;Härting, M.;
Thin Solid Films,2009, 517,3484.
30.Cai,X.;Riedl, B.;Zhang,S.;Wan,H.;Composites Part A: Applied
Science and Manufacturing,2008, 39,727.