Authors
1 Department of Chemistry, NMKRV College for Women, Bangalore 560 011, India
2 Department of Chemistry. Karnataka University. Dharwad 58000, India
3 Emeritus Fellow, All India Council for Technical Education, New Delhi, India. SET’s College of Pharmacy, Dharwad-580 002.
Abstract
Nanocomposite microspheres of chitosan (CS) with magnesium aluminum silicate (MAS) and enteric coated with poly(vinyl acetate phthalate) (PVAP) have been prepared and examined for controlled release (CR) of capecitabine, an anticancer drug. The microspheres have been characterized by X-ray diffraction (XRD) to study the drug distribution, DSC to understand thermal stability and Fourier transform infrared (FTIR) spectroscopy to investigate the chemical interactions as well as to assess the structures of drug-loaded formulations. Surface morphology of the microspheres was investigated by scanning electron microscopy (SEM). The size distribution of the formulated microspheres studied by particle size analyzer was in the range of 303-350 μm, while their encapsulation efficiencies ranged from 50 to 58%. Equilibrium swelling of the microspheres was measured in both pH 1.2 and 7.4 media. In vitro release of capecitabine has shown a dependence on polymer-clay composition, amount of crosslinking agent and extent of enteric coating. The formulations extended the release of drug up to 32 h. The enteric coating with PVAP effectively reduced the burst release of the drug in gastric pH medium. The present method offers promising results for controlled release of short-acting drugs. Copyright © 2018 VBRI Press.
Keywords
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