Sudha C. Angadi; Lata S. Manjeshwar; Tejraj M. Aminabhavi
Abstract
Nanocomposite microspheres of chitosan (CS) with magnesium aluminum silicate (MAS) and enteric coated with poly(vinyl acetate phthalate) (PVAP) have been prepared and examined for controlled release (CR) of capecitabine, an anticancer drug. The microspheres have been characterized by X-ray diffraction ...
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Nanocomposite microspheres of chitosan (CS) with magnesium aluminum silicate (MAS) and enteric coated with poly(vinyl acetate phthalate) (PVAP) have been prepared and examined for controlled release (CR) of capecitabine, an anticancer drug. The microspheres have been characterized by X-ray diffraction (XRD) to study the drug distribution, DSC to understand thermal stability and Fourier transform infrared (FTIR) spectroscopy to investigate the chemical interactions as well as to assess the structures of drug-loaded formulations. Surface morphology of the microspheres was investigated by scanning electron microscopy (SEM). The size distribution of the formulated microspheres studied by particle size analyzer was in the range of 303-350 μm, while their encapsulation efficiencies ranged from 50 to 58%. Equilibrium swelling of the microspheres was measured in both pH 1.2 and 7.4 media. In vitro release of capecitabine has shown a dependence on polymer-clay composition, amount of crosslinking agent and extent of enteric coating. The formulations extended the release of drug up to 32 h. The enteric coating with PVAP effectively reduced the burst release of the drug in gastric pH medium. The present method offers promising results for controlled release of short-acting drugs. Copyright © 2018 VBRI Press.
Eagambaram Murugan; Chennakesavapuram R Akshata; Annie Stephy
Abstract
Capecitabine (CPT) is an oral antineoplastic prodrug of 5-Flurorouracil (5-FU), administered for the treatment of metastatic breast and colorectal cancers. Detection of trace quantity of Capecitabine in pharmaceutical drug dosages is very crucial and essential owing to its life threating toxic adverse ...
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Capecitabine (CPT) is an oral antineoplastic prodrug of 5-Flurorouracil (5-FU), administered for the treatment of metastatic breast and colorectal cancers. Detection of trace quantity of Capecitabine in pharmaceutical drug dosages is very crucial and essential owing to its life threating toxic adverse effects. In this study, an effective conducting nanohybrid namely, MWCNT-PAMAM (G3)-AuNps was developed and characterized by Raman, FT-IR, SEM and HR-TEM techniques. The developed conducting nanohybrid was used for fabrication of effective and stable active electrode viz., GCE-MWCNT-PAMAM (G3)-AuNps which in turn demonstrated for effective sensing of trace quantity of Capecitabine i.e., at a concentration of 5 x 10-12 M under lower potentials. The reduction of Capecitabine was investigated through cyclic voltammetry in the presence of H2SO4 (pH 1.54) as supporting electrolyte. The presence of Capecitabine exhibited an irreversible reductive peak potential at ~0.835 V which was observed from mixed diffusion-adsorption controlled processes. The mechanism for electrochemical-chemical reduction, trace and rapid determination of Capecitabine are reported. This newly developed electrode has a potential to sense/ detect the Capecitabine at the concentration of 5 x 10-12 M under lower potentials. Further, it is expected that there is a strong scope for quality control in pharmaceutical formulates. Copyright © 2017 VBRI Press.
