Authors

Department of Chemistry, Birla Institute of Technology-Mesra, Ranchi 835215, Jharkhand, India

Abstract

In this article, we have reported the synthesis of Polyacrylamide grafted Barley (Ba-g-PAM) by free radical copolymerization technique. Ceric ammonium nitrate (CAN) was used as a free radical initiator for this synthesis process. Various grades of Ba-g-PAM were synthesized by varying the CAN and AM concentration. The swelling properties of these different grades of Ba-g-PAM were performed in different pH media like 1.2, 6.8& 7.4 at 250C and 370C. All grades showed better swelling properties at 370C than 250C. The matrix tablets of different grades of grafted materials were prepared by following the standard protocol using 5-flurouracil as a model drug. The swelling and erosion property of each matrix tablet was performed at 370C in different pH media like 1.2, 6.8& 7.4. The percentage of drug released from different matrix tablets was determined in different pH media like 1.2, 6.8& 7.4 (similar to GI tract). The drug release kinetics was also determined with the help of percentage drug release results. The matrix tablet of best grade i.e. Ba-g-PAM5 follows non-fickian kinetics, so, the diffusion rate of drug from matrix tablet and the relaxation rate of the polymer chains in the matrix tablets are comparable.  The acute oral toxicity test was performed on the basis of Organization of Economic Co-operation and Development (OECD) guidelines, showing non-toxic behavior. The above results support that the controlled release of
5-flurouracil in the colonic region has been successfully carried out. This developed material may be of help in the colon cancer treatment. Copyright © 2017 VBRI Press

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