Document Type : Research Article
Authors
1 G.H. Raisoni College of Engineering, Nagpur, Maharashtra 440016, India
2 Department of Chemistry, RTM Nagpur University, Nagpur, Maharashtra 440033, India
3 Rajiv Gandhi College of Engineering & Research, Nagpur, Maharashtra 441110, India
Abstract
A series of new phenothiazine derivatives of sulfonamide dyes was designed, synthesized & evaluated for their potent anti-cancer activities. The compounds were designed on the basis of molecular docking studies. Firstly they were docked with three different anticancer target enzymes viz. topoisomerase-II, aromatase and CDK2 and on the basis of dock score the designed compounds were synthesized. All synthesized compounds were bio-evaluated for their in-vitro anti-cancer action which displayed adequate results in agreement with the outcome of docking study.
Keywords
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