TY - JOUR ID - 15992 TI - Design, Synthesis and Bio-evaluation of New Phenothiazine Derivatives of Sulfonamide Dyes as Anticancer Agents JO - Advanced Materials Proceedings JA - AMP LA - en SN - 2002-4428 AU - D. Shanti, Manoj AU - D. Shanti, Kaveri AU - Meshram, Jyotsna AU - Raut, Manisha AU - Nandekar, Kamlakar AD - G.H. Raisoni College of Engineering, Nagpur, Maharashtra 440016, India AD - Department of Chemistry, RTM Nagpur University, Nagpur, Maharashtra 440033, India AD - Rajiv Gandhi College of Engineering & Research, Nagpur, Maharashtra 441110, India Y1 - 2020 PY - 2020 VL - 5 IS - 3 SP - 1 EP - 6 KW - Docking KW - topoisomerase-II KW - aromatase enzyme KW - CDK2 KW - phenothiazine derivatives of sulfonamide KW - anticancer evaluation DO - 10.5185/amp.2020.030406 N2 - A series of new phenothiazine derivatives of sulfonamide dyes was designed, synthesized & evaluated for their potent anti-cancer activities. The compounds were designed on the basis of molecular docking studies. Firstly they were docked with three different anticancer target enzymes viz. topoisomerase-II, aromatase and CDK2 and on the basis of dock score the designed compounds were synthesized. All synthesized compounds were bio-evaluated for their in-vitro anti-cancer action which displayed adequate results in agreement with the outcome of docking study. UR - https://amp.iaamonline.org/article_15992.html L1 - https://amp.iaamonline.org/article_15992_8801bc432eb3586c4abcc99cea47d8a3.pdf ER -