Cinvestav-IPN, Unidad Saltillo, Ramos Arizpe, 25900, México


The effect of mixed ferrites nature and that of several coatings on the magnetic properties and thus, on the heating ability of nanoparticles, was studied. The Mg0.4Ca0.6Fe2O4 and Mn0.5Ga0.5Fe2O4 ferrites, synthesized by sol-gel method, followed by heat treatment, were coated with oleic acid + Pluronic® F-127, carboxymethyl-dextran sodium or polyvinylpyrrolidone. An average particle size of 12 and 15 nm was obtained for the Mg-Ca and Mn-Ga ferrites, respectively. Samples, before and after coating, revealed a heating capacity over 42°C and a superparamagnetic behaviour. The compounds accomplished the requirements of heating ability and specific absorption rate for magnetic hyperthermia treatment. The Mn0.5Ga0.5Fe2O4 system was more efficient than the Mg0.4Ca0.6Fe2O4 system. Copyright © 2018 VBRI Press.


1.Tran, N. &Webster, T. J. Magnetic nanoparticles: biomedical
applications and challenges. J. Mater. Chem.20,8760 (2010).

DOI: 10.1039/c0jm00994f

2.Baronzio, G. & Hager, E. Hyperthermia in cancer treatment: a
primer. Hyperthermia In Cancer Treatment: A Primer1,(Springer
US, 2006).

DOI: 10.1007/978-0-387-33441-7

3.Pankhurst, Connolly, J., Jones, S. K. & J, D. Applications of
magnetic nanoparticles in biomedicine. J. Phys. D ...12,(2003).
(available at

Cheng, F. Y. et al.Characterization of aqueous dispersions of
Fe3O4 nanoparticles and their biomedical applications.

26,729738 (2005).

De-León-Prado, L. E. et al.Synthesis and characterization of
nanosized MgxMn1−xFe2O4 ferrites by both sol
-gel and thermal
decomposition methods.
J. Magn. Magn. Mater.427,230234
6.Zhang, L. &Wu, Y. Sol-Gel Synthesized Magnetic MnFe 2 O 4
Spinel Ferrite Nanoparticles as Novel Catalyst for Oxidative
Degradation of Methyl Orange. 2013,(2013).

DOI: 10.1155/2013/640940

7.Ahmad, R. et al.Improved electrical properties of cadmium
substituted cobalt ferrites nano-particles for microwave
application. J. Magn. Magn. Mater.405,2835 (2016).


8.Sánchez, J. et al.Sol-gel synthesis of MnxGa1?xFe2O4
nanoparticles as candidates for hyperthermia treatment. Solid State
Sci.42,1375513760 (2016).

DOI: 10.1016/j.solidstatesciences.2013.07.010

Sato Turtelli, R. et al.Interplay between the cation distribution and
production methods in cobalt ferrite. Mater. Chem. Phys.132,
832838 (2012).


9.Jasso-Ter??n, R. A. et al.Synthesis, characterization and
hemolysis studies of Zn(1???x)CaxFe2O4 ferrites synthesized by
sol-gel for hyperthermia treatment applications. J. Magn. Magn.
Mater.427,241244 (2017).

DOI: 10.1007/s10856-014-5180-x

10.Reyes-Rodríguez, P. Y. et al.Structural and magnetic properties of
Mg-Zn ferrites (Mg1−xZnxFe2O4) prepared by sol-gel method. J.
Magn. Magn. Mater.427,268271 (2017).

DOI: 10.1016/j.jmmm.2016.10.078

11.Escamilla-Pérez, a. M., Cortés-Hernández, D. a., Almanza-Robles,
J. M., Mantovani, D. & Chevallier, P. Crystal structure of
superparamagnetic Mg0.2Ca0.8Fe2O4 nanoparticles synthesized
by solgel method. J. Magn. Magn. Mater.374,474478 (2015).


12.Saldívar-Ramírez, M. M. G. et al.Study on the efficiency of
nanosized magnetite and mixed ferrites in magnetic hyperthermia.
J. Mater. Sci. Mater. Med.25,22292236 (2014).

DOI: 10.1007/s10856-014-5187-3

13.Sulaiman, N. H., Ghazali, M. J., Majlis, B. Y., Yunas, J. & Razali,
M. Superparamagnetic calcium ferrite nanoparticles synthesized
using a simple sol-gel method for targeted drug delivery. Biomed.
Mater. Eng.26,S103S110 (2015).DOI: 10.3233/BME-151295

14.Bolden, N. W., Rangari, V. & Jeelani, S. Synthesis of drug loaded
iron oxide nanoparticles. in ICCM International Conferences on
Composite Materials(2009).

15.Maensiri, S., Sangmanee, M. & Wiengmoon, A. Magnesium
Ferrite (MgFe2O4) Nanostructures Fabricated by Electrospinning.
Nanoscale Res. Lett.4,221 (2008).


16.Weng, C.-H., Huang, C.-C., Yeh, C.-S., Lei, H.-Y. &Lee, G.-B.
Synthesis of hollow, magnetic Fe/Ga-based oxide nanospheres
using a bubble templating method in a microfluidic system.
Microfluid. Nanofluidics7,841 (2009).