TY - JOUR ID - 16005 TI - Molecular Docking Study of Substituted Chalcone Compounds as Potential Cyclin-Dependent Protein Kinase 2 (Cdk-2) Inhibitors JO - Advanced Materials Proceedings JA - AMP LA - en SN - 2002-4428 AU - M. Dadure, Kanhaiya AU - G. M. Haldar, Animeshchandra AU - Kar Mahapatra, Debarshi AD - Department of Chemistry, Bajaj College of Science College, Wardha 442001, Maharashtra, India AD - Department of Applied Chemistry, Priyadarshini Bhagwati College of Engineering, Nagpur 440009, Maharashtra, India AD - Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur 440037, Maharashtra, India Y1 - 2020 PY - 2020 VL - 5 IS - 4 SP - 1 EP - 3 KW - Chalcone KW - Thiophene KW - CDK-2 KW - Docking KW - Inhibitors DO - 10.5185/amp.2020.040413 N2 - The present investigative studies involve molecular docking study of substituted thiophene-based chalcone compounds (A1-A9) against anti-cancer therapeutic target cyclin-dependent protein kinase-2 (Cdk-2) (PDB ID: 1HCL) for identifying and developing potential inhibitors. Few imperative physicochemical properties such as stretching, bending, stretching-bending, torsion, Non-1,4 VDW, 1,4 VDW, total steric energy for frame, and total energy of the best inhibitors have also been determined. UR - https://amp.iaamonline.org/article_16005.html L1 - https://amp.iaamonline.org/article_16005_24157191ca8582bb77f3c1082f99465c.pdf ER -